Neuronal polarization
نویسندگان
چکیده
منابع مشابه
AMPK signaling in neuronal polarization
Neuronal polarization, the process by which neurons form multiple dendrites and an axon from the soma, is the first critical step in the formation and function of neural networks. Polarization begins with the rapid extension of a single neurite to produce an axon of impressive size and complex geometry, while the remaining sister neurites differentiate into dendrites. The extensive biosynthesis...
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A mature neuron is typically polarized both structurally and functionally, with a single long axon and several dendrites. Neuronal polarity is essential for unidirectional signal flow from somata or dendrites to axons. The initial event in establishing a polarized neuron is the specification of a single axon. Early in neuronal development, one immature neurite becomes differentiated from other ...
متن کاملAMP-activated protein kinase regulates neuronal polarization
Question: Does the adenosine 5=monophosphate (AMP)-activated protein kinase (AMPK) signaling cascade have a role in neuronal polarization? Background: The differentiation of a single neurite into an axon, which involves increased protein and membrane synthesis as well as the intracellular trafficking of these products, is a metabolically costly process. The AMPK signaling cascade has a major ro...
متن کاملImplication of Wnt signaling in neuronal polarization.
Wnt ligands comprise a large family of secreted glycoproteins that control a variety of developmental processes including cell polarization in diverse organisms. Through various receptors present on receiving cells, Wnts initiate intracellular signaling cascades resulting in changes in gene transcription or cytoskeleton reorganization. Recently, several lines of evidence have suggested the role...
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The ability to coat surfaces with pre-determined patterns of biomolecules by soft lithography has found use in areas ranging from fundamental biology to translational medicine, such as tissue engineering and diagnostics. However, existing surface patterning techniques (e.g., microcontact printing and traditional lithography) are unable to pattern several biomolecules in a single step. Here we i...
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ژورنال
عنوان ژورنال: Development
سال: 2015
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.114454